1.6.6 Peripheral opioid-receptor antagonists
NICE TA 345 (July 2015) recommends naloxegol as an option for treating opioid induced constipation in adults whose constipation has not adequately responded to laxatives.
An inadequate response is defined as opioid-induced constipation symptoms of at least moderate severity in at least 1 of the 4 stool symptom domains (that is, incomplete bowel movement, hard stools, straining or false alarms) while taking at least 1 laxative class for at least 4 days during the prior 2 weeks. If only 1 laxative class has been taken, this should be the stimulant type.
Please note, sample information has been entered into Chapters 1 and 2 only and although fairly clinically accurate, it is not guaranteed. The information was entered during April and May 2017 and drugs will have subsequently been randomly added during telephone demonstrations.
Only for initiation by a physician with expertise in palliative care