Drug Status Key

  • Preferred
  • On Formulary
  • Specialist Initiation
  • Shared Care
  • Hospital Only
  • Under Review
  • New on System

1.5.3 Drugs affecting the immune response


  1. Azathioprine and mercaptopurine have a role in maintenance of remission in people with Crohn’s disease. Methotrexate is also indicated where patients cannot tolerate or have contraindications to azathioprine and mercaptopurine or where these drugs are ineffective. See NICE CG152 (October 2012)
  2. If switching formulation of mercaptopurine, full haematological monitoring is advised as the products are not bioequivalent.
  3. Ciclosporin has a role in the hospital setting for severe acute ulcerative colitis under specialist supervision. – see NICE CG166 (June 2013)

Please note, sample information has been entered into Chapters 1 and 2 only and although fairly clinically accurate, it is not guaranteed. The information was entered during April and May 2017 and drugs will have subsequently been randomly added during telephone demonstrations.

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