Drug Status Key

  • Preferred
  • On Formulary
  • Specialist Initiation
  • Shared Care
  • Hospital Only
  • Under Review
  • New on System

1.3.4 Prostaglandin analogues

Misoprostol is included as one option for NSAID prophylaxis. However, NSAIDs should be avoided in patients with dyspepsia wherever possible and a PPI is the preferred agent for gastroprotection. Refer also to NSAID section in BNF chapter 10. Effective contraception must be used in women of childbearing age. Contraindicated in pregnancy.

The dose of misoprostol required to treat benign gastric and duodenal ulceration or NSAID associated ulceration is 800micrograms per day in divided doses. However, colic and diarrhoea may limit the dose.

Please note, sample information has been entered into Chapters 1 and 2 only and although fairly clinically accurate, it is not guaranteed. The information was entered during April and May 2017 and drugs will have subsequently been randomly added during telephone demonstrations.

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