1.3.4 Prostaglandin analogues
Misoprostol is included as one option for NSAID prophylaxis. However, NSAIDs should be avoided in patients with dyspepsia wherever possible and a PPI is the preferred agent for gastroprotection. Refer also to NSAID section in BNF chapter 10. Effective contraception must be used in women of childbearing age. Contraindicated in pregnancy.
The dose of misoprostol required to treat benign gastric and duodenal ulceration or NSAID associated ulceration is 800micrograms per day in divided doses. However, colic and diarrhoea may limit the dose.